The deficiency of folic acid in the mother s body can lead to anencephaly in their children. Neural tube defects ntd refer to a set of conditions in which an opening in the brain or the spinal cord remains exposed from the very early stages of foetal development.
Here we modeled zinc deficiency in mouse embryos and used live imaging and molecular studies to determine how zinc deficiency affects neural tube closure.
Neural tube defects caused by deficiency in. This paper highlights the most recent medical literature about folate deficiency. A neural tube defect is a birth defect involving the malformation of body features associated with the brain and spinal cord. Folate deficiency has a well established teratogenic effect leading to an increasing risk of neural tube defects.
Brosnan 4 john t. The association seen between reduced neural tube defects and folic acid supplementation is due to a gene environment interaction such as vulnerability caused by the c677t methylenetetrahydrofolate reductase mthfr variant. An ntd originates from and is characterized by incomplete closure of the neural tube which is an organizer and precursor of the central nervous system.
Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Copp 1 and nicholas d e. Other common causes of neural tube defect in babies are understood to be.
Abstract micronutrition isessential forneuraltubeclosure andzincdeficiency. Huili li1 2 jing zhang1 2and lee niswander1 2. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation.
Glycine decarboxylase deficiency causes neural tube defects and features of non ketotic hyperglycinemia in mice yun jin pai 1 kit yi leung 1 dawn savery 1 tim hutchin 2 helen prunty 1 3 simon heales 1 3 margaret e. Embryos cultured with the zinc chelator tpen failed to close the neural. A deficiency of folate itself does not cause neural tube defects.
Can occur along the entire length of the spinal column or can be restricted to a small area in the spinal column. Neural tube defects occur as a result in the failure of neural tube closure that produces defects of varying degrees. Tin the us one in 1000 births is affected by neural tube defects ntd.
Folic acid deficiency folic acid or vitamin b is very important for the healthy development of the foetus. Micronutrition is essential for neural tube closure and zinc deficiency is associated with human neural tube defects. Brosnan 4 andrew j.