Genetic role of vitamin b12 cobalamin in spina bifida. Taking folic acid before and during the st three months of pregnancy does not guarantee the baby will not have sb but it can significantly reduce the risk.
People at risk of sb may have genetic variations gene mutations that alter the metabolism of cobalamin.
Folic acid deficiency spina bifida. We assumed mandatory folic acid fortification at 200 μg day of folic acid fully protects against fap sba reducing the prevalence of spina bifida and anencephaly to 0 5 per 1 000 live births. Thus the deficiency of cobalamin and folic acid and any interruption in the process of its synthesis leads to the development of neural tube defects like spina bifida. A folate deficiency increases the risk of spina bifida and other neural tube defects.
Overall 59 countries met our criteria for implementing mandatory folic acid fortification of wheat and or maize flour in 2017. Couples who ve had one child with a neural tube defect have a slightly higher chance of having another baby with the same defect. The synthetic form found in supplements and fortified foods is called folic acid.
Research has shown that if women who could become pregnant were to take a multivitamin with folic acid the risk of neural tube defects like spina bifida could be reduced by up to 70. Family history of neural tube defects. Any change in the mthfr gene or decreased concentration of cobalamin in relation with polymorphism in methionine synthase reductase the enzyme that starts cobalamin.