Folic acid is the common type of folate found in many vitamins and supplements. It helps reduce the risk of your baby being born with neural tube defects ntds.
Folic acid or folate is one of the b vitamins important for the healthy growth of your unborn baby.
Folate neural tube defects. With 4 mg folic acid daily it may take 20 weeks to reach red blood cell folate levels between 1050 and 1340 nmol l optimal for reduction of the neural tube defect risk. The role of supplements and food fortification. Periconceptional folic acid significantly reduces the risk of neural tube defects.
Why you may need a higher dose. Therefore folic acid supplementation should be started 5 6 months before conception. Why you need to take folic acid.
Dosage limits for folic acid. A protective effect of folate against the development of neural tube defects ntds specifically anencephaly and spina bifida is now well recognized having been established by a chain of clinical research studies over the past half century. A deficiency of folate itself does not cause neural tube defects.
Neural tube defects have a birth incidence of approximately 1 in 1 000 in american caucasians and are the second most common type of birth defect after congenital heart defects. This article summarizes the more important of these stu. The most common ntds are open spina bifida myelomeningocele and anencephaly 206500 detrait et al 2005.
The association seen between reduced neural tube defects and folic acid supplementation is due to a gene environment interaction such as vulnerability caused by the c677t methylenetetrahydrofolate reductase mthfr variant. Neural tube defects such as spina bifida are one of the most common congenital malformations. Studies have demonstrated that periconceptional folic acid supplementation can prevent 50 or more of ntds such as spina bifida and.
Proper folic acid dosage. No scientific studies exist that show that supplements containing other types of folate such as 5 mthf can help prevent neural tube defects. Folic acid is the only type of folate shown to help prevent neural tube defects severe birth defects of the brain or spine.
About neural tube defects. It is difficult to achieve optimal levels of folate by diet alone even with fortification of flour especially because flour consumption in canada is slightly decreasing. Folate and neural tube defects.
Current evidence suggests that folic acid supplementation in the periconceptional period either alone or in combination with other vitamins and minerals can prevent neural tube defects. The american academy of pediatrics endorses the us public health service usphs recommendation that all women capable of becoming pregnant consume 400 μg of folic acid daily to prevent neural tube defects ntds. A protective effect of folate against the development of neural tube defects ntds specifically anencephaly and spina bifida is now well recognized having been established by a chain of clinical research studies over the past half century.